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PHA 568487

CAS No. 527680-56-4

PHA 568487 ( —— )

Catalog No. M24500 CAS No. 527680-56-4

The quinuclidine PHA 568487 is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 80 In Stock
25MG 152 In Stock
50MG 282 In Stock
100MG 507 In Stock
500MG 1062 In Stock
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Biological Information

  • Product Name
    PHA 568487
  • Note
    Research use only, not for human use.
  • Brief Description
    The quinuclidine PHA 568487 is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
  • Description
    The quinuclidine PHA 568487 is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
  • Synonyms
    ——
  • Pathway
    Endocrinology/Hormones
  • Target
    AChR
  • Recptor
    α7 nicotinic acetylcholine receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    527680-56-4
  • Formula Weight
    288.3
  • Molecular Formula
    C16H20N2O3
  • Purity
    >98% (HPLC)
  • Solubility
    H2O:<40.44mg/ml (100mM); DMSO:<40.44mg/ml (100mM)
  • SMILES
    O=C(c(cc1)cc2c1OCCO2)N[C@@H]1C(CC2)CCN2C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Shilliday F, et al. Multiple species metabolism of PHA-568487, a selective alpha 7 nicotinic acetylcholine receptor agonist. Drug Metab Lett. 2010 Aug;4(3):162-72.
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